Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration
نویسندگان
چکیده
منابع مشابه
Mechanisms of axonal spheroid formation in central nervous system Wallerian degeneration.
Wallerian degeneration of the CNS is accompanied by axonal dystrophy or swelling. To understand the mechanisms by which swellings arise, we studied their spatiotemporal dynamics, ultrastructure, composition, and the conditions that affect their formation in vivo and ex vivo. In contrast to peripheral nerve axons, lesioned optic nerve (ON) axons in vivo developed focal swellings asynchronously w...
متن کاملThe slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids are terminal endbulbs of axon stumps, but swellings may also occur on unbroken axons and their role in axon loss re...
متن کاملThe slow Wallerian degeneration gene, Wld, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
Correspondence: Dr Michael Coleman, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK E-mail: [email protected] *W. Mi and B. Beirowski contributed equally to this work ZMMK and Institute for Genetics and Department of Anatomy I, University of Cologne, Cologne, Germany, Division of Neuroscience, University of Edinburgh, Edinburgh, The Babraham Institute, Babraham, Cambridge, UK,...
متن کاملdefence mechanisms of the central nervous system
the close relationship between the immune system and the central nervous system (cns) has been well-studied. the cns regulates almost all the functions of the immune system; however, the effect and/or the control of the immune system on the cns has not been well-studied yet. recent reports suggest that the cns has its own defence mechanism(s). in this review, attempts have been made to discuss ...
متن کاملWallerian Degeneration in Central Nervous System: Dynamic Associations between Diffusion Indices and Their Underlying Pathology
BACKGROUND Although diffusion tensor imaging has been used to monitor Wallerian degeneration, the exact relationship between the evolution of diffusion indices and its underlying pathology, especially in central nervous system, remains largely unknown. Here we aimed to address this question using a cat Wallerian degeneration model of corticospinal tract. METHODOLOGY/PRINCIPAL FINDINGS Twenty-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2010
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e3181da84db